I've used a combination of roles for this system, but it depends on the personal available and how they interact with the wide players.
For example, if I wanted use Foden in an attacking role, then I use a Mez (A) on the same side a Winger (S), so that it encourages Foden to underlap into the space beyond the Winger. Works vice-verca too.
As mentioned by others, some roles seem to get in the way of the IWB (S) and DM (which I prefer on Defend duty).
The roles I've used were:
Physical players: CM (A) and BBM (S)
Technical players: Mez (S), RPM (S), AP (A), CM (A), Mez (A),