These things are very much about personal opinion. In general, I'd agree with @Johnny Ace in that a) I'll try and minimize the number of TI's where possible and b) you've made the 433 more aggressive by upping the ante to Attacking.
Role wise - again personal opinion, however I've always felt Salah played higher than Mane, so you could reduce Mane to IF(S) - he'll still be plenty attacking with the rest of the settings you have (possibly even more so if you remove the overlapping).
Hendo was a pressing monster in the late Rodgers/early Klopp phase - you could easily go BWM(S) there.
Klopp has always described Fab as his lighthouse - is DLP(D) the way to go here. Although capable of decent passing, his role was more about breaking up play and stopping the opposition in their tracks - maybe just a DM(D) would suffice.
It may be a minor error, but you have VvD as BPD in the 4231, but CD in the 433. Personally, to have him hit those cross field balls to Mo, I'd have thought he should be a BPD in both (and perhaps not Matip?). I would also suggest there's a Cover/Stopper option that you could explore with these two.
Final thought - I know a lot of people have Play out of Defence to stop the ball being punted upfield, but you have Shorter Passing selected which should help discourage, so is it needed, especially if you want VvD hitting those spaces behind the opposition's full back for Mo to run on to.