I wouldn't say I struggle. Been playing a quick run through with Man Utd to work out the ME. Should finish 2nd in the league.
That said playing away causes my players to somehow forget how to pass the ball to each other, dally on the ball, take really really poor touches (Varane decided to just trap a ball and leave it inside the penalty area in Europa League match once). But I can't quite work out why because I'll play at home with the same tactic or slight variation of it against the same team and dominate. I'm not expecting world beating performances away from home but I go from 2-3 xG to barely being able to get a shot away.
I typically start here. Though I may invert the midfield depending on the opposition. Recently played Bayer Leverkusen in a Europa league tie with this same formation. Struggled to draw 1-1 away from home (It wasn't exactly this tactic but same principles) and my players could not/would not connect a pass. Played at home and smashed them 4-0. I'm happy to take my medicine and sit back and play a low block against more skillful teams and grind out a result. And I recognize that some days teams just don't have it and that's part of the game. I've contemplated pressure of games, end season mentality, player fatigue. I actually did the most risky thing any FM manager could do. I praised them at halftime in the 4-0 home win v BL04 despite being up on 1-0 to help lift some of the pressure because I'd been hammering the don't get complacent message for a few weeks.
Just feels like either the away team gets nerfed or the home team gets buffed in this game so far. But that doesn't feel like a satisfactory answer.
Typical changes include setting my LB to FBs if I sense danger of a counter or to balance out individual mentality. I might play a low block with a standard line and push the trigger press to much more. The 4-3-3 variant that I play will tyipcally see the DM on Anchor, Erikson on APs on the right and Fernandes as a Mezzala-a on the left. my wingers will be set to IWs and IFs. Generally results in an overload on the left side that Fernandes/Rashford/Sancho can take advantage of and score.