I've only played about 4 league games so far but won them all. That does include United away and Arsenal at home. I am using this tactic:
Tactic
Main team is:
GK: Mendy
DR: James
DC: Koulibaly
DC: Tiago/Fofana
DL: Chilwell
MC: Enzo
MC: Kovacic
AMC: Mount
AML: Felix
AMR: Pulisic
FC: Kai
It focuses down the left so utilises Felix. My only issue with that is James doesn't get involved as much. Kante, Sterling, Mudryk also played a fair bit. Enzo is a bit wasted as DLP (D) but still does well.
In terms of transfers I only signed Zakharyan, mainly as he usually signs a new deal and the release clause goes up. Loaned out RLC, Badiashile, Broja, Chukwuemeka. I would have kept the last 3 around but the squad is really bloated and the players that I would probably get rid of: Ziyech, Auba etc are unsellable for any value. Hoping to give them bit parts and sell in the summer.