Yes, absolutely.
433 specifically works really well for it I've found because you can keep the same midfield 3 which gives a lot of solidity in the middle.
4231's problem for me is that I don't like CAM as a role in FM when it's behind a lone striker, I don't like their interplay. If it's a CAM behind two strikers it works much better for me.
What I've been trying recently with my Chelsea team is this:
The IF ends up being the main goalscorer for me with this so far. I tried multiple roles for the CAM and so far AP-A works with the lone striker, but I'd need to test it with other teams first to be sure whether I truly like it or not because my Chelsea team is really stacked with talent so it's a bad example of what does/doesn't work since the league isn't as balanced as it should be in the year 2041.
442 is a good formation for this style of football too, it becomes really hard to break down.