I have a a bit simmilar issue, when you play a save, where you use multiple manager profiles and a player gets an injury, that auto pauses the game and forces you to take him off, if you play against another one of your profiles, the buttons (the on the top right stop working and you cannot continue the game. Also instead of the button with the 2 vertical lines as pause button, there is now one with the word pause in it, like you were an observer instead of a manager. As Note though I have 3 manager profiles active in that save.